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In the early 1990s Cynthia Kenyon and others produced the first C. elegans nematode worms to exhibit significantly extended longevity through a single gene mutation, in daf-2, the nematode version of the insulin-like growth factor 1 (IGF-1) receptor, and went on to map the relevant nearby biochemical landscape of these mutants. It is perhaps overly…

Funded by the SENS Research Foundation and allied philanthropists, the researchers at the Spiegel Lab are working on the tools needed to build the means to remove glucosepane cross-links from aged tissue. Like clearance of senescent cells, this is one of the more promising near-term approaches to rejuvenation therapies because it is just the single,…

When the population as a whole is aging because of historical changes in birth and mortality rates, meaning that an increasing percentage of people are older rather than younger with each passing year, it is perfectly possible to observe both a growth in the total number of cases of age-related disease and at the same…

Cigarette smoke seeps into everything—clothing, furniture, rugs. Now, researchers at the University of California, Riverside, suggest that even this third-hand smoke (THS) can be harmful to our health.   In the study, published in Clinical Science, researchers exposed mice to similar levels of smoke found in smokers’ homes. After six months, the mice showed cell damage in their…

IMAGE: Cannabis and Cannabinoid Research is the only peer-reviewed open access journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the biochemical mechanisms of endocannabinoids. view more  view more  Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, September 19, 2017–In the roundtable entitled “Expert Panel on Understanding Cannabis: Medicine, Society,…

A Ludwig Cancer Research study has uncovered a new mechanism by which cancer cells evade destruction by the immune system. The paper, led by Camilla Jandus of the Lausanne Branch of the Ludwig Institute for Cancer Research, describes how immune cells known as group 2 innate lymphoid cells (ILC2s) are recruited by leukemic cells to…

IMAGE: This is the fortress: The blood brain barrier. view more  view more  Credit: Samah Jassam New model may help science overcome the brain’s fortress-like barrier Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier. The brain…

PHILADELPHIA — (Sept. 19, 2017) — In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells (“TABs”) in melanoma progression and resistance to targeted therapy. This study provides a molecular mechanism that governs the cross-talk between TABs and tumor…

IMAGE: This is Elizabeth Shpall, M.D. view more  view more  Credit: MD Anderson Cancer Center HOUSTON — Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by a team led by clinicians at The University of Texas MD Anderson Cancer…

It is estimated that up to 75 percent of breast cancer survivors experience problems with cognitive difficulties following treatments, perhaps lasting years. Currently, few science-based options are available to help. In the journal Cancer, University of California San Diego School of Medicine researchers report in a pilot study of 87 female breast cancer survivors, an…

Human papillomavirus (HPV) testing detects a higher number of precancerous cervical lesions than cytology-based Pap smears in a female population including a proportion offered HPV vaccination, according to a new study published in PLOS Medicine by Karen Canfell of Cancer Council New South Wales, Australia, researchers at the Victorian Cytology Service, Melbourne, Australia, and colleagues….

Sindoor — a cosmetic powder sold in the United States and used during Hindu religious and cultural ceremonies — has unsafe levels of lead, according to a Rutgers University study. Rutgers researchers from the School of Public Health reported that 83 percent of the samples collected from the U.S. in New Jersey and 78 percent…

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