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Bisphosphonates are used as a treatment for osteoporosis. Like most pharmaceutical therapies for age-related disease, they have a set of unpleasant side-effects, but a couple of studies have found evidence for long-term bisphosphonate use to reduce mortality in older individuals. In one case the effect was quite large, a dramatic decrease in mortality versus the…

Calorie restriction improves health and extends life in most species and lineages tested, while both Protein restriction and intermittent fasting can provide similar but usually lesser packages of benefits. Once delving into the details of the biochemistry involved, however, the picture becomes very complex, and is still quite uncertain. These strategies probably work through overlapping…

Enlarge this image Emily Blair, a medical assistant at the Colon, Stomach and Liver Center in Lansdowne, Va., takes a blood pressure reading for Robert Koenen. New guidelines say that patients should have their arm resting on a surface while taking a reading and both feet should be placed flat on the ground. Josh Loock/NPR…

IMAGE: Yu Yamaguchi, M.D., Ph.D., is a professor in the Human Genetics Program at SBP. view more  Credit: SBP La Jolla, Calif., November 20, 2017 – Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple…

Columbus, Ohio – A new study by researchers at The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James) identifies a substance released by pancreatic cancer cells that protects them from attack by immune cells called macrophages. The study found that the substance, called Gdf-15, might be…

WEST LAFAYETTE, Ind. – Purdue University researchers have found a method of identifying biological markers in small amounts of blood that they believe could be used to detect a myriad of diseases, infections and different medical conditions at early stages. Jeffrey Rhoads, a professor in Purdue’s School of Mechanical Engineering; George Chiu, a professor in…

LUGANO, 20 November 2017 – Osimertinib improves progression-free survival compared to standard first line therapy in Asian patients with EGFR-mutated non-small-cell lung cancer (NSCLC), according to the Asian subset analysis of the FLAURA trial presented at the ESMO Asia 2017 Congress (1), sumultaneously published in The New England Journal of Medicine. (2) EGFR mutations occur…

So-called “triple-negative” breast cancer is a particularly aggressive and difficult-to-treat form. It accounts for only about 10 percent of breast cancer cases, but is responsible for about 25 percent of breast cancer fatalities. Triple-negative breast cancer earns its name because, unlike other breast cancer subtypes, its cells test negative for estrogen and progesterone receptors, as…

IMAGE: Visualization of the DNA repair proteins XPC (in green) and MUTYH (in red) to sites of UV-induced DNA damage within the nucleus (in blue), within a human cell. view more  Credit: CeMM/ Abdelghani Mazouzi (Vienna, Nov. 17, 2017) The destructive force of UV radiation on DNA molecules is only fully visible, when repair mechanisms fail:…

LUGANO, 20 November 2017 – A randomised trial in 650 patients has confirmed the safety and efficacy of a new second line treatment for metastatic colorectal cancer, researchers report at the ESMO Asia 2017 Congress. (1) Oral fluorinated pyrimidines have been investigated to replace intravenous 5FU in colorectal cancer (CRC). Capecitabine combined with oxaliplatin (XELOX)…

IMAGE: William Kim, MD, and colleagues have demonstrated the ability of cognitive computing to scour large volumes of data from scientific studies and databases to identify potentially relevant clinical trials or… view more  view more  Credit: UNC Lineberger CHAPEL HILL – A University of North Carolina Lineberger Comprehensive Cancer Center-led study has demonstrated the ability of…

A recent study showed approximately one-fifth of patients with cancer experienced post-traumatic stress disorder (PTSD) several months after diagnosis, and many of these patients continued to live with PTSD years later. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings highlight the need for early identification, careful monitoring, and…

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