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Clearance of metabolic waste from the brain via fluid drainage pathways is becoming an important topic in the context of age-related neurodegeneration, as is noted by the authors of this open access review paper. There is good evidence to suggest that drainage of cerebrospinal fluid is a significant path for the removal of wastes, such…

18 Jul 2018 18 Jul 2018 Vinculin Upregulation Improves Cardiovascular Health and Extends Life in Flies Loading… Loading… Researchers here report on a single gene alteration in fruit flies, increased levels of vinculin, that improves cardiovascular function in later life and increases life span. Effect sizes in flies are much larger than those in humans,…

Previous research has shown that cannabinoids can help lessen side effects of anti-cancer therapies. Now a new British Journal of Pharmacology review has examined their potential for the direct treatment of cancer. Phytocannabinoids are the most notable type of cannabinoid, and they occur naturally in the cannabis plant. Studies have shown that cannabinoids may stop…

Pancreatic cancer carries a very poor prognosis as most patients are diagnosed at an advanced stage. Now a new BJS (British Journal of Surgery) study indicates that breath analyses may help detect pancreatic cancer earlier, when curative treatments may be possible. For the study, investigators examined volatile organic compounds in breath samples from patients with…

In an Addiction Biology study, the estimated prevalence of very high risk drinking level (VHRDL, defined as drinking >100 g of ethanol per day) in 13 European Union countries was 0.74-0.85 percent, with a risk of disease or injury of 13.5 per 100 people with VHRDL per year. In an additional analysis in 9 European…

In addition to focusing on curing or prolonging the life of patients with cancer, it is important to also address mental health aspects of cancer care, especially because there is an elevated incidence of death by suicide in this patient population. A new Psycho-Oncology analysis uncovers opportunities to mitigate the risk of death by suicide…

A study in Molecular Oncology indicates that examining the protein and RNA in leftover materials from routine diagnostic tests for breast cancer may lead to more accurate diagnoses. Using samples from fine needle aspiration from 25 patients with breast cancer and 33 patients with benign lesions, investigators found that such a strategy could distinguish all…

A new study in the Journal of the National Cancer Institute suggests that CT scans, commonly used in medical imaging, may increase the risk of brain tumors. The use of computed tomography (CT) scans has increased dramatically over the last two decades. CT scans greatly improve diagnostic capabilities (which improve clinical outcomes) but they deliver…

17 Jul 2018 17 Jul 2018 Oisin Biotechnologies Produces Impressive Mouse Life Span Data from an Ongoing Study of Senescent Cell Clearance Loading… Loading… Oisin Biotechnologies is the company working on what is, to my eyes, the best of the best when it comes to the current crop of senolytic technologies, approaches capable of selectively…

Researchers appear to have found a novel way to sabotage fibrosis, the condition in which regenerative processes run awry with age and cells begin building scar-like structures that disrupt normal tissue function. The approach involves blocking TLR4 signaling. Fibrosis is a feature of the decline of many organs; liver, lung, kidney, heart, and so forth….

Inhibitors of mechanistic target of rapamycin (mTOR) are arguably the most reliable of the current crop of compounds that slow aging by targeting stress response mechanisms, improving cellular health and resilience to some degree. The observed gain in life span in mice and lower species is likely to be much larger than the outcome achieved…

New Orleans, LA – LSU Health New Orleans is one of 12 universities and health care entities conducting the first large-scale, multi-institutional study to help determine why African- American men are at higher risk for developing aggressive prostate cancer and dying from it. The $26.5 million RESPOND, or Research on Prostate Cancer in Men of…

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