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Mortality rates for cancer have diminished slowly and steadily over the past few decades. This is a matter of prevention on the one hand and improvements in early detection of cancer on the other. When caught early enough, even comparatively crude approaches to therapy have a decent chance of controlling and eliminating the cancer. This…

Senescent cells accumulate with age throughout the body. While only present in comparatively small numbers, even in very late life, their potent inflammatory signaling actively maintains a damaged, dysfunctional state in tissues and the body as a whole. Removing them dampens chronic inflammation and restores regenerative capacity. In animal studies senolytic therapies capable of removing…

IMAGE: Robert Wechsler-Reya, Ph.D., senior author of the paper, professor and director of the Tumor Initiation and Maintenance Program at SBP and program director of the Joseph Clayes III Research Center… view more  view more  Credit: Sanford Burnham Prebys Medical Discovery Institute (SBP) LA JOLLA, CALIF. – Jan. 23, 2019 – Chemotherapy and radiation are effective…

Scientists from Queen Mary University of London have received a grant from leading men’s health charity, Prostate Cancer UK, as London continues to lead the way in advanced prostate cancer research. Six separate grants worth over £2.5 million have been awarded in London as part of the charity’s Research Innovation Awards scheme which funds forward…

The American College of Cardiology will host the third Advancing the Cardiovascular Care of the Oncology Patient course in Washington on Jan. 25-27, 2019, bringing together top experts in both cardiology and oncology to review new and relevant science in this rapidly evolving field. Research continues to show the link between cancer and heart disease,…

Bottom Line: Less access to care and lower insurance coverage are among the reasons for racial disparities in breast cancer survival in the United States. Eligible beneficiaries in the U.S. Military Health System have insurance and access to care. This study examined whether racial differences existed in time to surgery and whether any differences in that…

Scientists at the University of British Columbia and BC Children’s Hospital are the first in Canada to use a new test for pediatric tumour analysis that may one day guide personalized treatments for children with cancer. Working with researchers at Children’s Hospital Los Angeles and the Keck School of Medicine at the University of Southern…

IMAGE: Left: The 23 pairs of chromosomes of cells in which autophagy is functioning look normal and healthy with no structural or numerical aberrations (each color represents a unique chromosome pair)…. view more  view more  Credit: Salk Institute LA JOLLA–(January 23, 2019) Just as plastic tips protect the ends of shoelaces and keep them from fraying…

IMAGE: The photograph shows an enlarged view of human bone cancer cells, which stopped growing when a drug molecule, GO289, jammed their circadian rhythm. Results appear in a study in Science… view more  Credit: USC Michelson Center for Convergent Bioscience A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock….

A cancer-killing, virus-based therapy showed promising effects against retinoblastoma – a tumor of the retina that affects mainly children – in mouse models and a pilot clinical trial. Although further work is needed, the therapy lays the groundwork for new treatment options for the cancer, which is currently treated with disfiguring surgery. Researchers estimate that…

For more than twenty years now, Richard Burt’s research teams have been working on the treatment of autoimmunity through the destruction and recreation of the immune system. Autoimmunity is a malfunction in the self-tolerance of immune cells, leading them to attack patient tissues. The malfunction is entirely contained in the immune system, so if the…

As is the case for other neurodegenerative conditions, Alzheimer’s disease has a strong inflammatory component. Even if other mechanisms are important, and there is very strong evidence for this to be the case, dysregulation of immune cells in the brain contributes notably to the progression of the condition. As recent work demonstrates, this dysregulation may…

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