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Cellular senescence is one of the root causes of aging. Nonetheless, the study of cellular senescence used to be a comparative backwater in aging research, and as a topic it was mostly of interest to cancer researchers seeking ways to better shut down the replication of cancerous cells. But there is nothing quite like having…

It remains the case that a great deal of aging research these days is purely observational, which is, I think, unfortunate. This is an age in which more than mere observation of aging might be achieved; the first interventions likely to reliably slow or reverse aspects of aging are making their way out of the…

Ilia Stambler, historian of our longevity science community, is in illustrious company in the author list for this open access position paper. Regular readers will recall that the World Health Organization (WHO) is among the most conservative and hidebound of institutions when it comes to the development of means to treat aging. The WHO positions…

A new study in the Journal of the National Cancer Institute, published by Oxford University Press, indicates that recent-onset type 2 diabetes may be early expression of pancreatic cancer. Diabetes was associated with a more than twofold higher risk of pancreatic cancer in African Americans and Latinos, but recent-onset diabetes was associated with a 2.3-fold…

The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators. Whole genome sequencing of tumours revealed mutations which are targetable by existing drugs used to treat lung cancer and melanoma. The results, published today (18 June) in Nature…

VIDEO: Researchers from Copenhagen University have studied the effect of the HPV-vaccine in the Danish population. view more  view more  Credit: The video may be distributed with creditation to University of Copenhagen, Faculty of Health and Medical Sciences. Girls in the first birth cohort to be offered and receive the HPV vaccine showed a lower degree…

One of the biggest helpers in our bodies’ ongoing efforts to prevent DNA mutations–mutations that can lead to cancer–is actually rather tiny. Electrons, as it turns out, can signal proteins that repair DNA to patch up DNA damage. More specifically, the movement of electrons through DNA, traveling between repair proteins bound to the double helix,…

Reduced cravings for cigarettes: after 12-hours without a cigarette, smokers rated their craving at 68 out of 100. After smoking a cigarette this reduced to 20. With both vaping products and iQOS it fell to only 40. Independent study by University of Leuven Thailand the worst country to be a vaper. UK the best. A…

IMAGE: This is Anthony Faber, Ph.D. view more  Credit: VCU Massey Cancer Center Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for the disease. Neuroblastoma, a cancer that begins in nerve tissue, is one…

IMAGE: The pipeline consists of a series of pre-computed (*) components, including a reference set of more than 13,000 tumor expression profiles representing 35 different tumor types, a collection of 28… view more  view more  Credit: CUIMC/Califano Lab NEW YORK, NY (JUNE 18, 2018)– Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly…

IMAGE: This image shows immune-focused disease module comparisons. view more  Credit: Nature Biotechnology Tel Aviv — June 18, 2018 — New data published in Nature Biotechnology, represents the largest ever analysis of immune cell signaling research, mapping more than 3,000 previously unlisted cellular interactions, and yielding the first ever immune-centric modular classification of diseases. These data…

IMAGE: This image of molecularly stained brain cells shows the AMPK target protein (green) in a large glioblastoma brain tumor that grew from transplanted human cancer cells in a mouse brain…. view more  Credit: Cincinnati Children’s CINCINNATI – Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. But…

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