IMAGE: The authors show that the long non-coding RNA called A-ROD (Activating Regulator Of DKK1 expression) is only functional the moment it is released from chromatin into the nucleoplasm. At this… view more
Credit: Evgenia Ntini
A Danish-German research team has shown that not only the where and when of long non-coding RNA expression is important for their function but also the how. The results can have a big impact on our understanding of dynamic regulation of gene expression in biological processes.
The cells of our body are divided into several compartments with specialized functions. DNA contains our genetic information and is localized in the cell nucleus where gene production is controlled. The nucleus is divided into the soluble nucleoplasm and the insoluble chromatin. Messenger RNA (mRNA) encodes for proteins, and the process of translation occurs in the cytoplasm. On the other hand, long non-coding RNAs primarily work in the nucleus, where they are essential components of controlling gene expression.
The research team has paid particular attention to long non-coding RNAs that can enhance the production of specific mRNAs, and hence proteins, in breast cancer cells. They show that the expression of long non-coding RNAs can result in particularly
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