A Possible Role for Sirtuin 7 in Osteoporosis

Researchers recently provided evidence to suggest that sirtuin 7 is involved in the imbalance between bone creation and and bone destruction that arises in old age, leading to osteoporosis. The extracellular matrix of bone tissue is constantly remodeled, with osteoclast cells breaking it down and osteoblast cells building it up. In older people the activity of osteoclasts begins to outweigh the activity of osteoblasts, weakening bones. There are many possible contributing causes, from the effects of inflammation on the generation of these cells to altered signaling environments in aged tissue affecting the pace at which the cells undertake work. Overall it has the look of a condition in which the proximate cellular cause of imbalanced bone remodeling is a fair way downstream from the roots of aging.

sirtuin 7osteoporosisextracellular matrixosteoclastosteoblasteffects of inflammation on the generation of these cellsthe roots of aging

Bone is a living tissue that is repeatedly broken down (bone resorption) and remade (bone formation) little by little every day. If this balance collapses and bone resorption exceeds bone formation, bone density decreases and can lead to osteoporosis. Sirtuins are enzymes that play important roles in controlling aging, stress responses, various areas of the metabolism, and several other body


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