A reliable, easy-to-use mouse model for investigating bone metastasis
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Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models. The new model could thus open a new chapter in the development of therapeutic strategies for bone metastasis and cancer progression.

In a study published in Nature Communications, a group of researchers led by Takahiro Kuchimaru* and Shinae Kondoh of Tokyo Institute of Technology (Tokyo Tech) present a mouse model that could greatly improve understanding of the underlying biology of bone metastasis.

It is widely known that metastasis — the spread of cancer cells from a primary tumor to other parts of the body — is one of the main causes of cancer mortality in humans. Bone metastasis commonly occurs when cancer cells spread to the bone from tumors originating, for example, in the prostate, breast, lung and kidney.

Experimental mouse models provide vital clues as to

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