A Review of Neurogenesis in the Aging Brain

Neurogenesis is the process by which new neurons are created and then integrated into existing neural circuits. Does neurogenesis take place in the adult human brain? That is once again a subject for debate after two decades of consensus, with the arrival of solid evidence for the absence of neurogenesis in adult humans, even as other researchers continue to produce data showing that it does take place. This newfound uncertainty contrasts with the well-established presence of neurogenesis in adult mice, the species that is the focus of the vast majority of research on this topic.

Neurogenesisneuronsneural circuitssolid evidence for the absence of neurogenesisshowing that it does take place

This an important topic. Along with synaptic plasticity, it determines the ability of the brain to repair itself, to recover from the variety of losses that occur with aging or injury. If neurogenesis does occur in adult humans, then there may be comparatively straightforward approaches that can boost the operation of this process in order to slow the impact of aging. If it does not occur in adult humans, then the prospect of repairing the aging brain becomes harder and more distant.

synaptic plasticity

The main reason behind the continuing interest in understanding the process


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