Senolytic compounds are those that selectively destroy senescent cells. As the accumulation of senescent cells is one of the root causes of aging, and senescent cells contribute directly to many specific age-related diseases, there is some interest in the development of effective senolytics. As is the case for any field of medical development, however, there are as many marginal and possible senolytic drugs as there are useful and proven senolytic drugs. The size of effect, the nature of the side-effects, and the quality of the evidence all matter greatly – indeed, this is the whole of the point when looking at whether a particular compound is viable or not.
The researchers here report on a few of the marginals and the possibles, compared against navitoclax, and observed no useful effect in a cell study. This is useful confirmatory work, even through the outcome is to be expected based on past evidence, particularly for quercetin. That said, it is important to note that different types of senescent cell have been shown to have quite different degrees of vulnerability to various classes of senolytic. It isn’t quite as straightforward as failure in one cell
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