Alex Huang, MD, PhD, receives $450,000 from Pediatric Cancer Research Foundation

Leading cancer researcher, Alex Huang MD, PhD, has received a $450,000 Basic Science grant from Pediatric Cancer Research Foundation to study targeted approaches for effectively eliminating metastatic osteosarcoma.

“We’re very excited to study an important cancer that occurs in adolescents, young adults and children,” said Huang, who is a professor of pediatrics at Case Western Reserve University School of Medicine. “We are now on the cusp of clinical trials, and look forward to offering hope to young patients with metastatic osteosarcoma in the near future.”

Osteosarcoma is a bone cancer that frequently occurs in children undergoing rapid growth. When the cancer spreads to places such as the lungs, the outcome can continue to be dismal despite intensive efforts over the last three decades of improving chemotherapy and surgical options. Lung osteosarcoma metastasis responds poorly to conventional chemotherapy, accounting for most of the mortality related to the disease. Huang’s research will mitigate this clinical challenge by understanding how macrophages, a subtype of immune cells, support osteosarcoma growth in lung tissues.

Huang, who is also the Theresia G. & Stuart F. Kline Family Foundation chair in pediatric oncology and the associate director of pediatric hematology-oncology fellowship program at University Hospitals Rainbow


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