Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. The study lays the foundation for finding new ways to treat prostate cancer, particularly for the most aggressive forms of the disease.
The multicenter study, which examined the genomes of tumors that grew and spread quickly, was led by Washington University School of Medicine in St. Louis and the University of California, San Francisco. The research appears July 19 in the journal Cell.
“This study could aid the search for better therapies to treat aggressive prostate cancer,” said co-first author Christopher A. Maher, PhD, an associate professor of medicine and an assistant director at The McDonnell Genome Institute at Washington University School of Medicine. “More immediately, the new information could help doctors find ways to identify which patients may develop aggressive tumors, and help guide their treatment decisions.”
More than 160,000 cases of prostate cancer are diagnosed each year in the U.S. While some 80 percent of prostate cancer patients have tumors that are slow-growing and have effective treatment options, about 20 percent of such patients develop the most aggressive forms of
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