ASCO & NEJM: AI plus ovarian suppression yields benefit in high-risk younger breast cancer patients
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CHICAGO – Premenopausal women with hormone receptor-positive, HER2-negative breast cancer and a high risk of recurrence who are treated with an aromatase inhibitor plus ovarian function suppression may gain 10 to 15 percent improvement in freedom from distant recurrence at eight years, according to a new clinical trial analysis reported at the annual meeting of the American Society of Clinical Oncology. The overall results of the TEXT and SOFT trials were concurrently published in the New England Journal of Medicine today.

The advantage was seen in women who received the aromatase inhibitor exemestane in addition to having their ovarian function suppressed (chemically or by surgery), compared to those who received tamoxifen plus ovarian function suppression, or tamoxifen alone. The combination of the aromatase inhibitor plus ovarian suppression is associated with more side effects than tamoxifen.

However, women categorized at low risk of recurrence, based on clinical and pathological characteristics, experienced minimal improvement in the risk of a distant recurrence when treated with the aromatase inhibitor plus ovarian function suppression instead of tamoxifen, reported Meredith Regan, ScD, of Dana-Farber Cancer Institute and the International Breast Cancer Study Group, the presenting and corresponding author of the report. Women judged to be

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