Aspirin Enhances Autophagy to Reduce Amyloid in Mouse Models of Alzheimer's
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03

Jul

2018

03

Jul

2018

Aspirin Enhances Autophagy to Reduce Amyloid in Mouse Models of Alzheimer’s

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A number of groups advocate the use of NSAIDs such as aspirin as a means to reduce risk and postpone the development of Alzheimer’s disease, based on the evidence accumulated in the past few decades. Aspirin is considered by some to be a calorie restriction mimetic that enhances autophagy, the cellular housekeeping mechanism that is required for calorie restriction to extend life in laboratory species. That said, I normally mention aspirin as a way to dampen excess enthusiasm for any new calorie restriction mimetic, autophagy-stimulating compound demonstrated to slow aging in the laboratory. After all, aspirin slows aging too, and to a similar degree, when tested in short-lived species. We shouldn’t expect any of the current crop of allegedly age-slowing compounds that influence these mechanisms to do much more for human health than aspirin has achieved. All sorts of beneficial effects will be observed, such as the one noted here, but at the end of the day the size of the effect matters greatly.

A regimen of low-dose aspirin potentially may reduce plaques in the brain, which will reduce Alzheimer’s disease

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Article originally posted at
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