Augusta, Ga. (April 19, 2019) – Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy. It is especially promising when this protein is dispensable for the growth of normal cells. Their discovery that UNC45A fits these criteria has researchers, led…

Wilmington, Del, April 18, 2019 – Scientists at Christiana Care Health System’s Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal. The…

Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which cells sense dysfunction of the proteasome – a cellular component that degrades unneeded or defective proteins – and respond in a previously undescribed manner, by editing the amino acid sequence of a key sensing protein. Proteasome dysfunction can lead to the type of buildup…

CLEVELAND–There’s a low-tech problem troubling the high-tech world of digital pathology imaging. The issue: Even as digital pathology makes rapid advances worldwide–with more physicians analyzing tissue images on “smart” computers to diagnose patients–there are no reliable standards for the preparation and digitization of the tissue slides themselves. That means poor quality slides get mixed in…

IMAGE: DNA molecules on an abstract technology-based background, illustrating the applications of biochemistry and genetic theory. view more  Credit: Artwork credited to vector artist whiteMocca and reprinted with permission from Shutterstock (ID: 663251594). Cold Spring Harbor, NY — Cold Spring Harbor Laboratory Press (CSHLP) announced the release of Next-Generation Sequencing in Medicine, available on its website…

LA JOLLA—Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body. Additionally,

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Jerry Shay, University of Texas Southwestern Medical Center, presenting at Undoing Aging 2019

VIDEO: New study targets Achilles’ heel of pancreatic cancer, with promising results view more  view more  LA JOLLA–(April 17, 2019) Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body. Additionally, tumor cells are encased in a “protective shield,” a microenvironment conferring resistance to many cancer treatment drugs….

IMAGE: Senthil K. Muthuswamy, PhD, of the Cancer Center at Beth Israel Deaconess Medical Center view more  view more  BOSTON – About one in eight women in the United States will develop breast cancer in her lifetime. The vast majority of these cancers rely on the hormone estrogen to grow. Estrogen-receptor positive (ER+) breast cancer tumors…

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