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09

Aug

2018

09

Aug

2018

Autophagic Flux Does Not Decline with Age in Dermal Fibroblasts

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Autophagy is a collection of cellular maintenance processes that recycle damaged or unwanted proteins and structures. It is generally considered to become less effective with age, and that this decline is an important aspect of aging, but nothing is simple in cellular biochemistry. For any well supported topic there are always exceptions and there is always at least some opposing evidence. Here, researchers report on data that shows autophagy to be just as active in old dermal fibroblasts as it is in the younger versions of such cells. It is hard to say what to make of that, given the sizable weight of all of the existing evidence for age-related dysfunction in autophagy, whether taken as a whole, or examining specific subsystems vital to the overall process.

Autophagy is an intracellular stress response that is enhanced under starvation conditions, and also when the cellular components are damaged. Aging accompanies an increase in intracellular stress and has significant impact on the skin. Since dermal fibroblasts are a powerful indicator of skin aging, we compared the autophagic activity of human skin fibroblasts between the

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Article originally posted at
www.fightaging.org

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