Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain “bad” bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.
Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research.
Authors: George Miller, MD, HL Pachter Professor in the Departments of Surgery and Cell Biology at New York University School of Medicine; Deepak Saxena, PhD, associate professor in the Department of Basic Science and Craniofacial Biology at New York University College of Dentistry.
Background: “The gut microbiome has been studied in many different cancers, including liver and colorectal cancer, and is shown to affect cancer progression,” said Miller. “Because the pancreas is remote from the gut, it is considered a sterile organ, and there haven’t been many studies that looked at the role of the gut microbiome in pancreatic cancer.”
How the Study Was Conducted and Results: The researchers also compared fecal samples from 32 patients with pancreatic ductal adenocarcinoma with fecal samples from 31 normal individuals and found that the bacterial
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