Bacteria play critical role in driving colon cancers
Share

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds. A second study in mice published concurrently by the same researchers shows a possible mechanism behind how one of these species spurs a specific type of immune response, promoting–instead of inhibiting–the formation of malignant tumors. Together, these findings could lead to new ways to more effectively screen for and ultimately prevent colon cancer, a disease that kills more than 50,000 people each year in the U.S. and is on the rise among younger adults age 20 to 50.

The complementary findings were published online Feb. 1 in Cell Host & Microbe and in the Feb. 2 issue of Science.

Cell Host & MicrobeScience

The Science findings describe a process in which these bacteria invade the protective mucus layer of the colon and collude to create a microenvironment–complete with nutrients and everything the bacteria need to survive–that induces chronic inflammation and subsequent DNA damage that supports tumor formation. These findings suggest a

read more...


Article originally posted at
www.eurekalert.org

Click here for the full story


CategoryAggregator News

© 2017 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

Powered by MMD