Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing
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IMAGE: Initiation of tumor angiogenesis up-regulates PSF1 promoter activity in endothelial cells (ECs). A: Skin vasculature 3 days after B16 melanoma cell injection into the mouse. White dashed line indicates localization… view more 

Credit: The American Journal of Pathology

Philadelphia, April 9, 2018 – Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study reported in The American Journal of Pathology describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics.

Combination therapy using angiogenesis inhibitors and anticancer drugs can improve drug delivery into tumor tissues and prolong progression-free survival. “Vascular normalization by angiogenesis inhibitors, such as vascular endothelial growth factor (VEGF) signaling inhibitors, is a promising method for improvement of chemotherapy. However, it is unclear how we can recognize the ‘window of opportunity’ for the tumor vascular normalizing period for effective timing of anticancer drug treatment. Therefore, biomarkers delineating this window are essential,” explained Nobuyuki Takakura, MD, PhD, Professor, Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Researchers showed that active proliferating vascular endothelial cells (ECs) in mice could be distinguished from dormant ones. They measured the promoter

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