Cancer genetic mutations not all treatable: System to rank relevance of mutations needed
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Lugano, Switzerland, April 11, 2018 – ESMO, the leading professional organisation for medical oncology, welcomes the latest reports from The Cancer Genome Atlas (TCGA) as a major resource for researchers across the world and calls for increased across-the-board commitment to translate these efforts into medical advances for the benefit of cancer patients. The TCGA collaboration conducted genome analysis, called the Pan-Cancer Atlas, on more than 10,000 tumours from 33 types of cancer and published 29 papers. (1)

“The studies highlight genomic alterations in cancer tissue, but while it is tempting to believe that they are all important, sometimes giving a drug matched to the mutation does not benefit patients,” said Prof. Fabrice André, Professor in the Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France, Chair of the ESMO Translational Research and Personalised Medicine Working Group, (2) Editor-in-Chief of ESMO’s flagship journal Annals of Oncology, (3) and Co-Chair of the ESMO Molecular Analysis for Personalised therapy (MAP) congress. (4)

“Large-scale clinical trials are now needed to determine which alterations can be treated and are therefore relevant from a medical perspective,” he continued. “Cancer geneticists have done an incredible job identifying the mutations; now oncologists and the broader oncology community

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