Raised blood pressure is to be avoided; the overwhelming weight of evidence associates it with a higher risk of age-related disease and shorter life expectancy. Some of that is because the proximate causes of raised blood pressure damage long term health in other ways as well, but in and of itself, even if there were…

Blood vessels stiffen with age, and this appears to be the primary cause of age-related hypertension, or raised blood pressure. That raised blood pressure in turn damages delicate tissues, increasing the pace at which ruptures occur in capillaries throughout the body. In the brain this causes many tiny, silent strokes over the years, adding up…

Today, I’ll point out an open access commentary in which the authors survey a number of lines of research into age-related dysfunction in the liver, all of which lead back to elevated levels of cyclin-dependent kinase 4 (CDK4). Some of this work involves investigation of the mechanisms of fatty liver disease, more properly known as…

20 Aug 2018 20 Aug 2018 The Synapses of Some Individuals Appear Resilient to Age-Related Protein Aggregation Loading… Loading… We all, to some degree, accumulate harmful protein aggregates in the brain with age, but only some people develop severe neurodegenerative disease as a result. The rest of the population remains mildly impaired. Why is this?…

Small, short doses of damaging cellular stress, such as that achieved through the application of heat, toxins, lack of nutrients, or raised levels of oxidative molecules, produce a net benefit to cell and tissue function. This is called hormesis. It occurs because cells react to short periods of stress with a lasting upregulation of maintenance…

IMAGE: The nuclei are in blue, alveolar type II cells in green and telomeres in red. Notice that lung cells treated with active telomerase present more intense telomeres indicating that they… view more  Credit: CNIO Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this…

IMAGE: Ralph Vatner, MD, PhD, in a proton radiotherapy gantry at the Cincinnati Children’s Hospital Medical Center/UC Health Proton Therapy Center. view more  view more  CINCINNATI–In a new study, University of Cincinnati (UC) researchers, in collaboration with Massachusetts General Hospital, have detailed the effect of radiation exposure on the development of hormone deficiency in pediatric and…

IMAGE: This is NFCR Senior Director of Development Janet Hines (Middle) with Institutional Giving Officer James Bragan and Safeway’s Eastern Division Senior Manager of Community and Public Affairs Beth Goldberg. view more  Credit: NFCR ROCKVILLE, MD – The National Foundation for Cancer Research (NFCR) is one of 13 local and regional organizations to be the recipient…

IMAGE: This is Tuuli Lappalainen, Ph.D., Core Faculty Member at the New York Genome Center, and Assistant Professor in the Department of Systems Biology at Columbia University. view more  Credit: New York Genome Center NEW YORK, NY (August 20, 2018) – Researchers at the New York Genome Center (NYGC) and Columbia University have uncovered a molecular…

A study published today in the journal JAMA Pediatrics reports that the method federal regulators use to monitor illegal underage tobacco sales fails to detect most stores that sometimes sell cigarettes to adolescents. The study, co-authored by several leading researchers of the topic, found that the federal method of a single purchase attempt by an…

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