Many age-related conditions are associated with solid aggregates in tissues that are formed of altered, damaged, or misfolded proteins. Protein aggregates are thought to be an important contributing cause of these diseases. In most cases the proteins involved in aggregate formation can and do appear in lesser amounts in young tissues, but we can point…

Researchers here report on two new senolytic compounds identified in the existing library of approved drugs, based on screening work in cell cultures. It is worth bearing in mind that drug candidates that demonstrate good results in cell culture quite often fail to show promise when tested in animals, so it is wise to be…

IMAGE: Dr. Eric C. Chang view more  Credit: Baylor College of Medicine Screening Food and Drug Administration (FDA)-approved compounds for their ability to stop cancer growth in the lab led to the finding that the drug flunarizine can slow down the growth of triple-negative breast cancer in an animal model of the disease. Led by researchers…

Today’s good news is that investor Jim Mellon has provided a sizable charitable donation to the SENS Research Foundation in support of their advocacy and rejuvenation research programs. The foundation is currently running their year end fundraiser, and this certainly helps to move the needle towards the goal: I hope that other high net worth…

The best epigenetic clocks correlate well with chronological age, and when the measure departs from chronological age, that difference correlates well with risk or incidence of age-related disease. A higher epigenetic age is seen in people known to have higher age-related morbidity and mortality. The tantalizing potential offered by these clocks is the ability to…

A geroprotector is a drug or supplement that either slows the underlying causes of aging or produces a greater resistance to the damage of aging. In either case health is prolonged and mortality decreased. Calorie restriction mimetics are the best example of the type, but the category is expansive enough to include well known drugs…

IMAGE: Fusicoccin, a phytotoxin, was converted to a series of antiproliferative agents for tumor cells by removing 12hydroxyl group. These compounds were shown to upregulate interaction of 1433 and a phospholigand… view more  Credit: Copyright © 2018, John Wiley and Sons Researchers at Shinshu University in Japan have discovered that editing the chemical properties of fusicoccins,…

Boston, MA — Men presenting with aggressive prostate cancer – Gleason Score of 9 or 10 – comprise most of those who will die from prostate cancer worldwide, and despite surgical removal of the prostate (radical prostatectomy), their cancer will recur more than 80 percent of the time. In a new multinational study of 639…

IMAGE: Purdue University researchers developed a technique to prepare polyol-modified nanoparticles so they locate cancerous cells and tumors by checking out blood vessels surrounding the tumors. view more  Credit: Yoon Yeo/Purdue University WEST LAFAYETTE, Ind. – Purdue University researchers have developed a technology aimed at making it easier to deliver cancer treatment to the right “address”…

The University of Texas MD Anderson Cancer Center applauds new actions announced today by the U.S. Food and Drug Administration (FDA) to limit the sale of most flavored electronic cigarettes (e-cigarettes) to age-restricted locations and require age-verification for online sales to lower the use of these products in children. In addition, the FDA plans to…

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