Sebastian Aguiar, geroscientist and Venture Fellow at Apollo Ventures, delivers the Lord Florey Lecture at Lincoln College, Oxford in November 2018. He was a Clarendon Scholar at Lincoln College, Oxford for his DPhil (PhD) on the biochemistry of aging. Aguiar presents topics such as the Silver Tsunami, promising industry developments, and exciting examples of healthspan…

Part of a series on the Hallmarks of Aging. Proteins don’t do everything in your body, but it’s fair to say they control everything. What they don’t do directly, they catalyze. Proteins handle everything from copying DNA, to stabilizing a neuron’s physical structure, to turning starch into sugar. If something goes wrong in the body,

Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe other approaches like targeting dysfunctional mitochondria are worth exploring in more depth. Apparently, improving mitochondrial function can decrease plaque burden and improve cognition in a mouse model. Why do cancer survivors have shorter lifespans than the rest

Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a neurodegenerative disease, there’s already something different about their patients’ brain cells. Action potentials flash across a long, thin arm protruding from the cell body in a healthy neuron, and…

That weathered, pruny exterior loved by photographers and loathed by nearly everyone else is, along with gray hair, perhaps the most easily recognizable feature of aging. But while most people’s objections to wrinkles are cosmetic, looking pretty is far from the only function required of the body’s largest organ. Chief among these functions is keeping…

Keeping one eye on your calories, and the other on that delicious-looking pumpkin pie? Don’t worry–your Thanksgiving sins probably won’t hurt your longevity as long as you’re fasting sometimes. You can thank your gut bacteria. What do insulin resistance and 17th century Prague have in common? The first rare variant that dramatically increases human lifespan…

The Hippo pathway controls cellular regeneration, so why not modify it to heal the heart after the scarring caused by a heart attack? Six weeks later, mouse hearts were good as new. modify it Cytomegalovirus (a herpes virus) infects over 90% of humans, often silently, but this mostly harmless little viral companion takes up far…

Laboratories studying the biology of aging are a menagerie of creatures great and small. From unicellular yeast and nematodes, all the way up to primates and even the faithful old Canis familiaris, animal models have opened up the aging process to our inspection in ways that human subjects wouldn’t have been able to match. It’s…

Had your curiosity piqued by our recent autophagy articles? Learn even more about this essential cellular process over at LEAF science! autophagyarticlesover at LEAF science Human trials of NMN, the NAD precursor found to slow aging in mice via sirtuin activation, begin this month. Cosmos goes in depth here. begin this monthhere Disappointing therapeutics based…

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