Part III of III in a series on the evolution of aging. (Part I, Part II) Part IPart II If all you had to go on was our genomes, you’d surely conclude that humans and rodents were nearly the same animal, with roughly 92% overlap. And luckily for the species that does science, the other…

Part of a series on the Hallmarks of Aging. Proteins don’t do everything in your body, but it’s fair to say they control everything. What they don’t do directly, they catalyze. Proteins handle everything from copying DNA, to stabilizing a neuron’s physical structure, to turning starch into sugar. If something goes wrong in the body,

Since the world of Alzheimer’s therapeutics hasn’t seen much practical benefit from targeting harmful proteins like amyloid-beta, maybe other approaches like targeting dysfunctional mitochondria are worth exploring in more depth. Apparently, improving mitochondrial function can decrease plaque burden and improve cognition in a mouse model. Why do cancer survivors have shorter lifespans than the rest

Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a neurodegenerative disease, there’s already something different about their patients’ brain cells. Action potentials flash across a long, thin arm protruding from the cell body in a healthy neuron, and…

All cells in your body have the same DNA, yet they express different proteins and do different things. How does that happen?  Various alterations in your cells affect the expression of genes, without altering their contents.  This is known as epigenetics. Cells of different tissue types have different epigenetic alterations that lead them to produce…

Keeping one eye on your calories, and the other on that delicious-looking pumpkin pie? Don’t worry–your Thanksgiving sins probably won’t hurt your longevity as long as you’re fasting sometimes. You can thank your gut bacteria. What do insulin resistance and 17th century Prague have in common? The first rare variant that dramatically increases human lifespan…

The normal mode of drug discovery is a pretty singular affair: one compound, one disease. This is enough for many traditional diseases, but when you’re facing a complex phenomenon built on innumerable pathways like aging, where existing treatments only scratch the surface, you need to get a little more creative. complex phenomenon built on innumerable…

Epigenetic markers “drift” as we age to cause unintended gene expression changes, but you might be able to slow this via caloric restriction. The epigenomes of rhesus monkeys on CR “appeared 7 years younger than their chronological age.” 7 years younger A vaccine for Alzheimer’s? It’s more likely than you think. Researchers at USC are…

Many people think of sleep almost as if it were a state of suspended animation, like turning off a computer so that it can cool down. But while your conscious mind and certain activities are dormant, much of your body is hard at work repairing damage, replenishing energy stores, and clearing away waste, in addition…

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