At its most dramatic, oxidative stress can rend DNA in two and predispose cells to mutations that ultimately result in cancer. But the less bombastic effects of reactive oxygen molecules are no less damaging, as they likely play a central role in the world’s number one killer, vascular disease, causing stroke and heart attack among

That weathered, pruny exterior loved by photographers and loathed by nearly everyone else is, along with gray hair, perhaps the most easily recognizable feature of aging. But while most people’s objections to wrinkles are cosmetic, looking pretty is far from the only function required of the body’s largest organ. Chief among these functions is keeping…

All cells in your body have the same DNA, yet they express different proteins and do different things. How does that happen?  Various alterations in your cells affect the expression of genes, without altering their contents.  This is known as epigenetics. Cells of different tissue types have different epigenetic alterations that lead them to produce…

Last week we heard the theoretical side of Dr. Michael Fossel’s mission to bring aging to its knees, and why his chosen point of attack was on the grand orchestrator of the body’s repair processes. This week he goes into the practical details: how does he plan to lengthen telomeres? What can we treat with…

Just like a well-folded sheet of paper, a tightly coiled segment of DNA doesn’t have much chance of being read. Our cells use this to their advantage, unspooling the genes they need at the moment with negatively charged acetyl groups, and using ‘eraser’ enzymes that remove these groups to roll up the instructions they don’t…

Lessons from 300 year old tubeworms: Lessons The low 0.67% mortality rate … supports longevity theory, which states that in the absence of extrinsic mortality threats, natural selection will select for individuals that senesce slower and reproduce continually into their old age. The low 0.67% mortality rate … supports longevity theory, which states that in…

A friendly genie appears in a puff of smoke and tells you that you’ll develop cancer 20 years hence. However, he offers to send you back in time to any point you wish, so that you can alter events in your life to prevent your cancer. Quickly now, he doesn’t have all day–when do you…

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