Long before the usual physiological signs, the withering of neurons and the gradual atrophy of the brain, that tip doctors off to the presence of a neurodegenerative disease, there’s already something different about their patients’ brain cells. Action potentials flash across a long, thin arm protruding from the cell body in a healthy neuron, and…

It’s been known for ages that individuals with two ApoE4 alleles were virtually destined to develop Alzheimer’s, but its link with the hallmark Alzheimer’s protein amyloid-beta was obscure, and it wasn’t clear what ApoE really did in the brain. Now researchers think that the culprit is the inflammatory response it triggers in the presence of…

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