This lengthy post walks through the process of setting up and running a self-experiment – a trial of one – with one of the various established mitochondrially targeted antioxidant compounds. Metrics are assessed beforehand and afterwards in order to shed some light on whether or not it worked, in the sense of improving one or…

This lengthy post covers the topic of setting up and running a self-experiment, a human trial of a single individual, to assess the senolytic effects of the peptide FOXO4 D-Retro-Inverso (FOXO4-DRI). This is the protein produced from the FOXO4 gene, with D-amino acids substituted for L-amino acids, reversing the chirality of the molecule. This means…

This post describes the results of an attempt to run a self-experiment using senolytic drug candidates derived from chemotherapeutics. Based on animal study data, these pharmaceuticals are potential means to selectively destroy some fraction of senescent cells in some tissues. This is of interest because the accumulation of senescent cells is one of the root…

This lengthy post walks through the process of setting up and running a self-experiment – a trial of one – of candidate senolytic drugs capable of removing some portion of the senescent cells that accumulate with age to cause aging and age-related disease. Metrics are assessed beforehand and afterwards in order to shed some light…

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