It’s looking increasingly likely that our little bacterial buddies have a major influence on neurodegenerative disease, from producing extra amyloid, to regulating inflammation, to generating free radicals. In mouse models of Alzheimer’s disease, a protein complex that forms part of the nervous system’s innate immune system binds to toxic amyloid-beta, promoting the formation of plaques.

The immune system degrades as we age. The elderly get sick more often, take longer to recover from illness or injury, are more prone to cancer, and more prone to autoimmune issues. Why this happens is a question scientists are just beginning to answer.   Like other cells, your immune cells are subject to telomere…

Can we “unlock a human’s inner salamander” with stem cell therapies? 3D-printed organs, uploaded brains, and disease-fighting nanobots: just a few of the tools Silicon Valley hopes to put in our anti-aging arsenal. Entrepreneur and biohacker Serge Faguet shares practical tips on what he sees as the six key areas for maximizing one’s own longevity…

(Part I of II.) Researchers at UNC Chapel Hill had an interesting mission: first, transform scar tissue (like the kind that forms after heart attacks) into ordinary cardiac muscle. Researchers at UNC Chapel Hill Of course, that wasn’t the interesting part. We’ve been able to transform cells of one type into cells of another, completely…

Epigenetic markers “drift” as we age to cause unintended gene expression changes, but you might be able to slow this via caloric restriction. The epigenomes of rhesus monkeys on CR “appeared 7 years younger than their chronological age.” 7 years younger A vaccine for Alzheimer’s? It’s more likely than you think. Researchers at USC are…

A study of centenarians finds a certain mutation of the growth hormone receptor gene is more common among men, but not women, compared to 70-year-old controls. But the modification doesn’t do what you might expect: though decreasing the amount of growth hormone absorbed, it also boosted protein expression when it was absorbed. This lead carriers to be…

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