Tuesday, May 15, 2018, CLEVELAND: Can the genetic makeup of their cancers predict how patients with lung cancer will respond to radiation therapy? And can this information be used to advance a genetically guided strategy for patients with these tumors? Cleveland Clinic researcher and radiation oncologist Mohamed Abazeed, M.D., Ph.D., has been awarded a $2 million grant from the National Cancer Institute (NCI) to delve into those and other related questions.
Dr. Abazeed’s overall objective for this award is to identify new genetic markers calibrated on the basis of radiation therapy effectiveness and new drug-radiation therapy strategies that more precisely and effectively target the most resistant lung tumors to radiation.
“Current radiation therapy regimens use a ‘one-size-fits-all’ approach, not taking into account the genetic content of individual tumors,” said Dr. Abazeed. “There is an urgent need to identify genetic markers that can recognize tumors that are more or less likely to respond to radiotherapy and translate these markers for clinical use. This more personalized approach not only can improve treatment responses, but it can also potentially reduce toxicity, resulting in an improved quality of life for survivors who received these treatments.”
Efforts to predict the response to radiotherapy thus
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