In most pancreatic cancer patients, the diagnosis is made when the disease is already advanced, and there is no effective treatment at present. There have been no significant advances to combat it in recent decades and unfortunately, its occurrence is on the increase. Now, a group of researchers from the Spanish National Cancer Research Centre (CNIO) may have found a new form of attack.
“This tumour is so aggressive and so complex that it is necessary to try and attack it from various sources, not only tumour cells. Our work opens the door to the design of future therapeutic strategies. However, it is still too early to think about its clinical use,” according to researchers in their publication, in the journal Proceedings of the National Academy of Science (PNAS).
One of the characteristics of pancreatic cancer is that the tumour cells are embedded in the stroma, which represents 90% of the tumour mass and which seems to form a barrier (physical and chemical) hindering treatment with inhibitors, chemotherapy and immunotherapy. Most of the studies have focused mainly on tumour cells, whilst the cells that form the stroma are the great unknown, in spite of different research groups proving that
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