Could less deadly therapies be a better way to keep cancer in check?
Share

While many cancer therapies initially can be very successful, tumors often return and spread when remaining cancer cells develop resistance to treatment. To combat this tendency, Frédéric Thomas of the French National Centre for Scientific Research proposes that cancer researchers take a lesson from our own immune system and explore “natural adaptive therapies.” Such an approach would mimic the immune system’s more restrained way of keeping cancer in check by gradually killing off cancerous cells. Ideally, these therapies would remove the evolutionary pressure that often leads to the spread of resistant tumors.

In Thomas’ article, publishing 2nd October in the open access journal PLOS Biology, he and his colleagues reason that the body has evolved anti-cancer responses that direct and slow the evolution of life-threatening cancer cells by not killing off too many cells too quickly. Natural adaptive therapies would use a similar approach to keep tumor size stable, while slowing the evolution of resistance. This strategy may be especially useful to prolong lifespan and quality of life in patients after a cancer has metastasized.

The authors also explore the risk that cancer immunotherapies may force the immune system to rapidly kill malignant cells in a way that undermines

read more...


Article originally posted at
www.eurekalert.org

Click here for the full story


CategoryAggregator News

© 2017 - LIFE EXTENSION ADVOCACY FOUNDATION
Privacy Policy / Terms Of Use

Powered by MMD