CTLA4 targeted therapy plus PD-1 targeted therapy could benefit women with ovarian cancer
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An analysis of the NRG Oncology clinical trial NRG-GY003 suggests that adding ipilimumab, a monoclonal antibody that targets the protein receptor CTLA-4, to a regimen with the checkpoint inhibitor nivolumab could improve the proportion with tumor response and progression-free survival hazard rates for women with recurrent epithelial ovarian cancer. These results were presented as a late-breaking abstract oral presentation at the 17th Biennial Meeting of the International Gynecological Cancer Society (IGCS) in Kyoto, Japan. This trial was sponsored by the Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI) and the agents were provided to NCI by Bristol Myers Squibb under the cooperative research and development agreements between Bristol Myers Squibb and NCI for the development of nivolumab and ipilimumab.

NRG-GY003 assessed the difference in tumor response proportions in 100 women between two treatment regimens over a period of six months. Participants on this trial were randomly assigned to either the first treatment arm (TA1) which received nivolumab alone, or the second arm (TA2) which received a combination of ipilimumab and nivolumab followed by maintenance nivolumab. Tumor response proportions were evaluated through RECIST 1.1 and secondary analyses included progression-free survival (PFS), overall survival (OS), and adverse events (AEs).

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