IMAGE: Monocytes after crossing the enflamed endothelial barrier. view more
Credit: © UNIGE
For a tumour to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumour vascularization is therefore an interesting anti-tumour therapy that has been explored over the last ten years. But how to be truly effective? By identifying two cytokines, key factors in the recruitment of blood cells essential to the formation of new blood vessels, and above all by deciphering how these factors interact simultaneously with blood vessels, researchers at the University of Geneva (UNIGE) are highlighting an additional way of controlling tumour progression. Moreover, their results, to be read in Nature Communications, suggest that the combined use of existing drugs or under development could significantly increase their efficacy.
Endothelial cells form the innermost layer of the blood vessels -the endothelium- and have the function of containing blood inside the vessels while allowing the passage of nutrients to tissues. When a new vessel is needed, the endothelial cells direct the process by allowing the recruitment of blood cells required for neovascularization, commonly called angiogenesis.
Monocytes, on the other hand, are part of the white blood cells circulating in the blood. Key elements
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