Daytime drowsiness increases risk of Alzheimer's

Depositing amyloid in brain tissue is the first known preclinical stage of Alzheimer’s and happens well before any obvious symptoms of dementia begin.

“We know that sleep is necessary to clear toxins and beta-amyloid in the brain,” said study author Prashanthi Vemuri, a research faculty member at the Mayo Clinic, where the study was done. “We also know that beta-amyloid causes sleep disruptions. So, it’s been a chicken and an egg problem.Prashanthi Vemuri“In our study, we wanted to know if excessive daytime sleepiness causes an increase of amyloid over time in people without dementia,” Vemuri continued. “And the answer was yes.””While further research is necessary, this study adds a new question that doctors can ask patients to assess risk and potentially intervene, said Dr. Richard Isaacson, Director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian, who was not involved in the study. “In fact, the findings will change the way i care for patients,” said Isaacson, “as i will now proactively ask about excessive daytime sleepiness as one of the many potentially modifiable risk factors for the disease.”



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