Researchers at the University of Texas at Arlington’s College of Nursing and Health Innovation have developed a new nanoparticle-based platform for simultaneous imaging and treatment of esophageal cancer.
Together with colleagues from The Ohio State University, researchers manufactured polypeptide nanoparticles, which have near infrared fluorescence for better tissue imaging. They also modified the nanoparticles with tumor targeting properties and then loaded the nanoparticles with a chemotherapy drug.
“This is precision medicine,” said Zui Pan, an associate professor of nursing and one of the corresponding authors of a paper on this nanoparticle, which is scheduled to be published in the journal Nature Communications this month. “It is harder to detect the esophageal cancer tumor. One common detection method is the use of an endoscopic probe, which shines a white light through your throat. But the problem is the tumor is embedded in the normal tissue and difficult to see. This will help detect the tumor and guide the surgeon to the area that is lit up and surgically remove it, or consider alternative therapies.”
Esophageal cancer, the sixth leading cause of cancer death worldwide, is responsible for nearly 16,000 deaths in the United States each year, according to the American
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