DOD grant to fund potential treatment for metastatic breast cancer
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IMAGE: Hollings Cancer Center researchers Ann-Marie Broome and Nancy DeMore combine their specialized interests to better understand a crucial mechanism that appears to drive tumor development. view more 

Credit: Medical University of South Carolina Hollings Cancer Center

A team of Medical University of South Carolina (MUSC) Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defense (DOD) to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development. The team will deploy innovative molecular imaging tools to study a crucial mechanism that appears to drive tumor development.

The study aims to find better ways to treat metastatic breast cancer that could replace current therapies, some of which have life-threatening side effects. Core to the work is Hollings Cancer Center researcher Nancy DeMore, M.D., a leading expert in angiogenesis and therapeutics created for breast cancer.

Angiogenesis, a key phase in malignant growth, involves how blood vessels form, develop and create a network to perfuse different types of solid tumors. Tumors need a blood supply to receive their nutrients and also as an escape route to metastasize to other organs, explains Ann-Marie Broome,

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