Early PSA testing could help predict prostate cancer among black men

TAMPA, Fla. – Prostate cancer is the second most common cancer in American men. But black men bear a disproportionate burden of its effects. It’s more common – and more than twice as deadly – among black men compared to their white counterparts. Yet the United States Preventive Services Task Force (USPSTF) recommendations for prostate cancer screening do not differentiate for race, leaving it to physicians and patients, ages 55 to 69, to reach an individual decision on whether and when to screen.

In a new study published in European Urology, Moffitt Cancer Center researchers, along with colleagues at Harvard T.H. Chan School of Public Health and Brigham and Women’s Hospital in Boston, demonstrated that a baseline prostate-specific antigen (PSA) level obtained from black men between ages 40 and 60 can strongly predict future development of prostate cancer and its most aggressive forms for years after testing.

The study builds on earlier work in the U.S. and Sweden which demonstrated a strong link between elevated midlife PSA levels and later development of prostate cancer among primarily white men. Given the pronounced racial disparities in prostate cancer, research on screening in African-American men has become a USPSTF priority.

The investigators


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