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10

Jul

2018

10

Jul

2018

Endothelial Cell Dysfunction as the Early Manifestation of Small Vessel Disease

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Cerebral small vessel disease is a form of age-related dysfunction in the smaller blood vessels of the brain, associated with damage to the white matter of the brain and the onset of dementia. It is thought that the increased blood pressure of hypertension and consequent physical stresses on blood vessel walls is the primary cause of small vessel disease, but here researchers provide evidence pointing towards specific forms of change in signaling generated by dysfunctional endothelial cells that form the blood-brain barrier in blood vessel walls. That signaling degrades some of the necessary supporting operations of cells in nearby brain tissue – a situation that sounds similar to the outcome of cellular senescence and the senescence-associated secretory phenotype, though that topic isn’t mentioned at all in this paper. This endothelial cell signaling occurs prior to other aspects of small vessel disease, though itself must still be secondary to the underlying molecular damage of aging in and around blood vessel cells: senescence, cross-linking, and so forth.

Cerebral small vessel disease (SVD) affects arterioles in the brain, increasing risk of stroke and causing

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Article originally posted at
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