Evidence does not support statin use for conditions other than heart disease

Annals of Internal Medicine Tip Sheet

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information.

1. Evidence does not support statin use for conditions other than heart disease


Despite studies suggesting benefits for conditions beyond cardiovascular disease (CVD), the evidence does not support revising current statin prescribing guidelines. Findings from an evidence review and meta-analysis are published in Annals of Internal Medicine.

Statins are a group of medicines commonly used to lower cholesterol levels in the blood and their benefits for reducing the risk of heart disease and stroke are well-established. Some studies have suggested that statins may help patients with non-CVD conditions, but the evidence is not as clear.

Researchers led by the University of Edinburgh analyzed results from 256 studies that had investigated the benefits of taking statins for 278 non-CVD conditions. They found that statins can help to prevent deaths from kidney disease, which is already recognized in clinical guidelines, but there is no clear evidence that statins can help improve kidney function. Researchers also found evidence that statins can help slow cancer progression, but


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