Fluorescence imaging technique goes from micro to macro, moves closer to clinic
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IMAGE: Researchers have developed a macro-FLIM system that can analyze samples with areas up to 4 square centimeters. The new approach might one day find use in the clinic as a… view more 

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WASHINGTON — Researchers have scaled up a powerful fluorescence imaging technique used to study biological processes on the cellular level. Previously limited to samples just millimeters in area, the expanded approach can analyze samples with areas up to 4 square centimeters. With further development the new approach could find use in the clinic as a sensitive and precise method for identifying the edges of tumors during surgery.

The new macroscale imaging approach is based on a biological imaging technique known as fluorescence lifetime imaging microscopy (FLIM). “Our macro-FLIM system can not only obtain a sample’s structural information, but also allows observation of certain biochemical processes taking place within the sample,” said senior research scientist Vladislav Shcheslavskiy, Becker & Hickl, GmbH, Germany. “Although our goal is to develop this for clinical use, it could also be very useful in fundamental studies for probing biological processes as disease develops or investigating biological responses to different types of therapy.”

In The Optical Society (OSA) journal Optics Letters, the researchers demonstrate

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