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IMAGE: Dr. Alexander Bishop and a team from the Greehey Children’s Cancer Research Institute at UT Health San Antonio discovered a surprising connection between a breast cancer protein, BRCA1, and a… view more 

Credit: UT Health San Antonio

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma.

Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new questions about both Ewing sarcoma and BRCA1 biology,” said the study’s senior author, Alexander J.R. Bishop, D.Phil., of UT Health San Antonio.

Ewing sarcoma is a pediatric bone and soft tissue cancer. The median age of Ewing sarcoma patients is 15 years, and more than half of patients are adolescents. “Our team worked to identify why Ewing sarcoma is usually sensitive to standard cancer drugs, with the hope of finding new targets for therapy and revealing new ways to treat the disease if it returns or does not respond to standard therapies,” Dr. Bishop said.

Fused genes

Almost all Ewing sarcomas are caused by

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