The presence of the human high-risk papillomavirus (HPV) in the diagnosis of invasive cervical cancer is linked to a greatly improved prognosis compared with if high-risk HPV cannot be identified in the tumour, researchers at Karolinska Institutet in Sweden report in the scientific journal PLOS Medicine. The researchers believe that high-risk HPV can be another important prognostic marker that can inform the choice of therapeutic strategy.
High-risk human papillomavirus (hrHPV) is the leading cause of cervical cancer. However, whether the presence of hrHPV in the tumour tissue is of significance to the prognosis has been unclear. In this present study, researchers at Karolinska Institutet have therefore looked into a possible correlation between the presence of hrHPV in the tumour and survival rates for invasive cervical cancer (i.e. cervical cancer that has spread to surrounding tissues).
The researchers gathered information on all cases of invasive cervical cancer in Sweden between the years 2002 and 2011 (4,254 confirmed cases in total). They then collected HPV data from the regional biobanks for 2,845 of these women and compared survival data from national registers.
Their results show that the five-year relative survival rate for women with hrHPV-positive tumours was 74 per cent compared
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