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IMAGE: The prize winners from left: Pierre Chambon, Ronald M. Evans, and Bert W. O’Malley. view more 

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Columbia University has decided to award the Louisa Gross Horwitz Prize 2018 to:

Pierre Chambon

Institute of Advanced Study at the Strasbourg University and Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, France

Ronald M. Evans

and

Bert W. O’Malley

Baylor College of Medicine, Houston, TX, USA

“for their discoveries of how steroid hormones regulate the behavior of distant cells.”

Horwitz Prize Awarded for Work on Hormones

If you open up your medicine cabinet, it’s a safe bet that you’ll find a drug that targets a nuclear hormone receptor. Columbia University awards the 2018 Louisa Gross Horwitz Prize to Pierre Chambon, Ronald M. Evans, and Bert W. O’Malley for their research–spanning over 50 years–decoding how steroid hormones and nuclear receptors regulate cell function. This work has transformed our understanding of human physiology and disease.

Steroid hormones like cortisol and estrogens were first identified in the early 1900s. Researchers observed that these chemicals could travel long distances from one organ to another, and that they influenced a wide variety of biological processes including development, reproduction, growth, metabolism, and inflammation. But just how hormones worked remained a mystery for decades.

When molecular

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