A new Tel Aviv University study addresses the challenges of nanoparticle-based cancer-targeting strategies. It also suggests ways of refocusing the collaborative work of cancer researchers and clinicians to move the field forward from “the bench” to the patients.
The study follows landmark research published 10 years ago in Nature Nanotechnology that reviewed the full potential of actively targeted nanocarriers to revolutionize cancer care. The opinion piece garnered over 5,000 citations, making it one of the most influential analyses on the subject to date. That study was written by Prof. Dan Peer, director of the SPARK Tel Aviv Center for Translational Medicine at TAU’s Faculty of Life Sciences, and Jeffrey Karp, principal investigator at Brigham and Women’s Hospital and a professor at Harvard Medical School, Harvard University.
The updated review by Prof. Peer, Prof. Karp, Daniel Rosenblum, a doctoral student in Prof. Peer’s lab, and Dr. Nitin Joshi, an instructor at Harvard Medical School, was published recently in Nature Communications.
A hard road from the lab to the clinic
“When Dan and Jeff’s paper was published 10 years ago, there was great hope that nanocarriers in general and actively targeted nanocarriers in particular would transform cancer therapy,” Rosenblum says. “We’ve
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