IMAGE: UMass Amherst doctoral candidates Weican Wang, left, and Jianan Zhang, with others, suggest for the first time that inhibiting an enzyme known as soluble epoxide hydrolase, sHE, may abolish this… view more
Credit: UMass Amherst
AMHERST, Mass. – In a recent new finding, doctoral candidates Wiecang Wang and Jianan Zhang, with their advisor Guodong Zhang in the department of food science at the University of Massachusetts Amherst, report that they have identified a new molecular mechanism to explain the link between obesity and increased risk of colon inflammation, which is a major risk factor in colorectal cancer.
The research team, which includes scientists at the University of California Davis, suggest for the first time that inhibiting an enzyme known as soluble epoxide hydrolase, sHE, may abolish this risk of obesity-induced colonic inflammation, say Zhang and colleagues. They note that a few sEH inhibitors, known to be a factor in other inflammatory diseases but not colon cancer before, are now in human clinical trials.
Senior author Zhang says, “In our mouse studies, obesity-induced colon inflammation can be eliminated by inhibiting sEH. So we discovered a new therapeutic target for a very important disease.”
Because sEH inhibitors are already being
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