A study published in the journal Cancer Research, of the American Association for Cancer Research, reveals the therapeutic side of the Zika virus, which in 2015 made global public health authorities wary when the link between the infection of the virus during gestation and the birth of children with microcephaly was established.
Now, Brazilian researchers at the Center for Human Genome and Stem Cell Studies at the University of São Paulo have put the virus to good use showing, for the first time in animals, the deleterious effect of the injection of a low concentration of the purified virus on human embryonic brain tumors induced in mice with low immunity. The article is called “Zika virus selectively kills aggressive human embryonal CNS tumor cells in vitro and in vivo” and was published online this Thursday. (link not available yet)
The studies were conducted using human cell lineages derived from two types of embryonic tumors of the central nervous system (CNS): medulloblastoma and atypical teratoid rhabdoid tumor (AT/RT). These are tumors that mainly affect children under 5.
“CNS tumors are the most common solid tumors in children and adolescents,” explains Keith Okamoto, one of the study’s lead authors. “The peak incidence of medulloblastoma is
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