Researchers have developed a new type of sensor that acts like Velcro® for prostate cancer cells, sticking them to a modified frosted glass slide, like those used in science classes, so that they can be identified from blood samples. The low-cost method, reported in ACS Applied Materials & Interfaces, could help doctors better diagnose and monitor the disease.
In men with prostate cancer, some tumor cells exit the prostate gland and circulate in the blood. Detecting these cells could enable diagnosis at an earlier stage or help doctors assess whether treatment is effective. However, because circulating tumor cells are present in very small numbers, finding them can be a challenge. Previous sensors have been expensive and difficult to make. So Shudong Zhang and Shutao Wang wanted do develop a simpler, more cost-effective way to monitor prostate cancer cells in the blood.
The researchers based their device on frosted glass microscope slides, commonplace in high school science classes. The frosted area, which is used to hold and label the slide, is a sandblasted surface with tiny depressions. The researchers added a solution to the frosted slides that caused silica nanowires to grow on their surfaces, then they dangled antibodies that
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