Is exercise associated with lower risk of death for adult survivors of childhood cancer?

Bottom Line: Vigorous exercise is associated with reductions in the risk of death among adult survivors of childhood cancer.

Why The Research Is Interesting: In the general population, a healthy lifestyle that includes regular exercise is associated with a reduced risk of death. It is unknown whether that applies to adult survivors of childhood cancer who have an elevated risk of death because of the late effects of cancer treatment.

Who and When: 15,450 adult survivors of cancer diagnosed before age 21 at hospitals in the United States and Canada between 1970 and 1999 and enrolled in the Childhood Cancer Survivor Study

What (Study Measures): Self-reported vigorous exercise in metabolic equivalent task (MET) hours per week (exposures); all cause-mortality (primary outcome)

Study Design: This was an observational study. Researchers were not intervening for purposes of the study and cannot control all the natural differences that could explain the study findings.

Authors: Jessica M. Scott, Ph.D., and Lee W. Jones, Ph.D., of Memorial Sloan Kettering Cancer Center, New York, and coauthors

Results: Vigorous exercise for adult survivors of childhood cancer was associated with reductions in risk of death; in a subset of these survivors, increased exercise (an average of nearly


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