In the age of Big Data, cancer researchers are discovering new ways to monitor the effectiveness of immunotherapy treatments.
Researchers at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy developed a new way to use bioinformatics as a gathering tool to determine how a patient’s immune system responds to immunotherapy and recognizes its own tumor.
The study was published by Cancer Immunology Research June 12, 2018.
Senior author Kellie Smith, Ph.D., instructor of oncology at Johns Hopkins Kimmel Cancer Center, hopes enough data can be recovered to allow clinicians to determine the best course of treatment for patients by using a technique called MANAFEST.
“Once people are diagnosed with cancer, we hope to use this procedure to develop the best treatment options for them,” Smith said. “Previously, the technology (for MANAFEST) wasn’t there. In the last few years, the technology has evolved to enable us to come up with the way to analyze the data to help patients.”
Mutation-associated neoantigens (MANAs) are a target of antitumor T-cell immunity. However, there was a need to find out how well T-cells can recognize these MANAs in cancer patients.
The scientists changed how cultures were gathered to improve the accuracy of data
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