Large population study fails to find causal link between assisted reproduction and ovarian cancer
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Barcelona, 3 July 2018: Following concerns over many years that hormonal stimulation of the ovaries necessary for IVF may increase the risk of ovarian cancer, a nationwide cohort study from Denmark has now concluded that any perceived increase in risk is actually a statistical bias resulting from vigilant diagnosis at the time of treatment. The investigators were unable to make any causal association between the treatment and fertility drugs used and any excess risk of ovarian cancer.

The study matched every woman having IVF in Denmark between 1994 and 2015 with ten women from the background population and in its analysis found that assisted reproduction treatment (ART) “was not associated with a long-term increased risk of ovarian cancer which would be expected if caused by ovarian stimulating hormones”.

Results of this study, which finally included 58,472 women treated with IVF or ICSI and 549,210 non-treatment women, are presented today at the 34th Annual Meeting of ESHRE in Barcelona by gynaecologist Professor Anja Pinborg of the Fertility Department at Rigshospitalet, Copenhagen University Hospital, in Denmark. Each of the women were followed-up until a first cancer diagnosis, death or end of study period in 2015.

Results did show a slightly higher

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