Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults. While sex differences in the incidence and survival rates of glioma were known, researchers had not investigated whether genetic differences based on sex could cast light on potential differences in the risk profile of glioma between men and women.
Now, a team from Case Western Reserve University School of Medicine, together with an international consortium of researchers, have discovered that men and women have different genetic risk factors for developing glioma.
The research was recently published in Scientific Reports. The study involved the work of more than 35 investigators representing more than 30 universities, institutes and government agencies worldwide.
“Sex-stratified analyses in studies such as this can reveal novel insights into the known sex differences in glioma and provide previously unknown genetic risk associations,” said Jill Barnholtz-Sloan, Sally S. Morley Designated Professor in Brain Tumor Research at Case Western Reserve University School of Medicine, Associate Director for Bioinformatics at Case Comprehensive Cancer Center, and Associate Director for Translational Informatics at the Institute for Computational Biology. “This finding could provide an avenue to gaining a
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