Metastatic cancer cells modify bone remodeling with small RNA secretion in bone metastasis

IMAGE: In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype. MicroRNAs are transferred… view more 

Credit: Department of Physiology and Cell Biology,TMDU

Researchers at Tokyo Medical and Dental University (TMDU) find a secreted microRNA molecule that alters bone structure in late-stage prostate cancer

Tokyo – Prostate cancer is one of the most common cancers in men worldwide. In nearly three out of four patients the cancer causes metastasis, leaving the original site of the tumor and spreading to distant sites in the body. Metastatic prostate cancer cells often travel to bone, where they can affect bone structure and cause severe pain, pathological fractures, and spinal cord compression. A better understanding of the process that enables these cancer cells to remodel bone may aid in the search for new therapies. In a study published in Proceedings of the National Academy of Sciences, researchers at Tokyo Medical and Dental University (TMDU) report the discovery of an RNA molecule that may play a key role in bone restructuring caused by prostate cancer (Fig.1).

Proper bone development is maintained through a fine balance of bone-forming


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