More on TREM2 and Immune Function in Alzheimer's Disease
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11

Jan

2019

11

Jan

2019

More on TREM2 and Immune Function in Alzheimer’s Disease

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You might recall research published early last year on TREM2 as a possible regulator of immune cell clearance of amyloid in Alzheimer’s disease. Researchers here provide a further update on their investigations of the role of TREM2 in this process. To the degree that the immune system falters in this task of clearing metabolic waste with age, and to the degree that this issue can be reversed or overridden, this may prove to be a useful approach to age-related protein aggregates in the brain, and their contribution to neurodegenerative disease. As is so often the case, however, a treatment cannot be immediately and straightforwardly constructed based on manipulation of TREM2. Its relationship with immune cell activity and the Alzheimer’s disease state is complex.

A hallmark of Alzheimer’s disease is the formation of toxic deposits in the brain, so-called plaques. Specialized immune cells termed microglia protect the brain by clearing it from these toxic debris. TREM2 is a key factor in activating microglia and thus serves as an important target for novel therapeutic approaches. To further explore these therapeutic options, scientists undertook a detailed

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Article originally posted at
www.fightaging.org

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