IMAGE: Illustration of neutron diffraction data showing water distribution (red and white molecules) near lipid bilayers prior to fusion (left) and during fusion. Mapping the water molecules is key to understanding… view more
Credit: ORNL/Jill Hemman
New 3D maps of water distribution during cellular membrane fusion are accelerating scientific understanding of cell development, which could lead to new treatments for diseases associated with cell fusion. Using neutron diffraction at the Department of Energy’s Oak Ridge National Laboratory, researchers have made the first direct observations of water in lipid bilayers used to model cell membrane fusion.
The research, published in Journal of Physical Chemistry Letters, could provide new insights into diseases in which normal cell fusion is disrupted, such as Albers-Schönberg disease (osteopetrosis), help facilitate the development of fusion-based cell therapies for degenerative diseases, and lead to treatments that prevent cell-to-cell fusion between cancer cells and non-cancer cells.
When two cells combine during fertilization, or a membrane-bound vesicle fuses during viral entry, neuron signaling, placental development and many other physiological functions, the semi-permeable membrane bilayers between the fusing partners must be merged to exchange their internal contents. As the two membranes approach each other, hydration forces increase exponentially, which requires
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